Publications
Group highlights
For a full list see below or go to Google Scholar
We describe a step-by-step workflow, implemented in IsletLab, developed specifically for the study and simulation of pancreatic islets.
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
In this addendum I introduce IsletLab, a multiplatform application to analyze and reconstruct pancreatic islet architectures.
GJ Félix-Martínez
Based on the reconstruction algorithm proposed in a previous article, here we compare the architectures of mouse and human islets.
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
In this paper we develop an algorithm to reconstruct islet architectures from experimental data.
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
Single-channel currents are simulated using a deterministic chaotic model. In addition, whole-cell currents are also reproduced.
KL Juayerk-Herrera, GJ Félix Martínez, JL del Río-Correa, A Picones, JR Godínez-Fernández
J Theor Biol 508 (2021):110459.
We develop a model of the electrical activity of the human pancreatic delta cell based on single-channel currents.
GJ Félix-Martínez, V González-Vélez, JR Godínez-Fernández, A Gil
Int J Numer Meth Biomed Engng. 2020; 36:e3296
We published a review of the physiological hypotheses behind the mathematical models of the pancreatic β-cell.
GJ Félix-Martínez, JR Godínez-Fernández
A three-dimensional β-cell was modelled in order to simulate the Ca2+ transients produced during voltage-clamp experiments.
GJ Félix-Martínez, JR Godínez-Fernández
In this paper we developed a model to evaluate the effect of co-localization of the cell membrane and organelles for the formation of Ca2+ microdomains in chromaffin cells.
GJ Félix-Martínez, A Gil, J Segura, J Villanueva, LM Gutíerrez
Comput Biol Med 100, 165-175 (2018)
We performed simulations of the Ca2+ transient produced in a three-dimensional human β-cell as a response to action potential firing.
GJ Félix-Martínez, JR Godínez-Fernández
Biomed. Phys. Eng. Express 3 025020 (2017)
In this paper we used a mathematical model to explore the effects of impaired ATP production and glucose sensitivity on the electrical response and insulin secretion of human β-cells.
GJ Félix-Martínez, J Aspiroz-Leehan, R Ávila-Pozos, JR Godínez-Fernández
Rev Mex Ing Biomed, 35 (2) 2014
Full List
Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
J. Vis. Exp. (181), e63351
IsletLab: an application to reconstruct and analyze islet architectures
GJ Félix-Martínez
Islets 14.2 (2022):36-39
Comparative analysis of reconstructed architectures from mice and human islets
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
Islets 14.1 (2022):23-35
Reconstructing human pancreatic islet architectures using computational optimization
GJ Félix-Martínez, A Nicolás-Mata, JR Godínez-Fernández
Islets 12.6 (2020):121-133
Deterministic modeling of single-channel and whole-cell currents
KL Juayerk-Herrera, GJ Félix Martínez, JL del Río-Correa, A Picones, JR Godínez-Fernández
J Theor Biol 508 (2021):110459.
Comparative analysis of screening models for undiagnosed diabetes in Mexico
GJ Félix-Martínez, JR Godínez-Fernández
Endocrinol Diabetes Nutr 67 (5), 333-341 (2020)
Electrophysiological models of the human pancreatic δ‐cell: From single channels to the firing of action potentials
GJ Félix-Martínez, V González-Vélez, JR Godínez-Fernández, A Gil
Int J Numer Meth Biomed Engng. 2020; 36:e3296
Mathematical models of electrical activity of the pancreatic β-cell: A physiological review
GJ Félix-Martínez, JR Godínez-Fernández
Islets 6 (3), e949195 (2014)
Modeling Ca2+ currents and buffered diffusion of Ca2+ in human β-cells during voltage clamp experiments
GJ Félix-Martínez, JR Godínez-Fernández
Math Biosci (2015) 270, 66-80
Modeling the influence of co-localized intracellular calcium stores on the secretory response of bovine chromaffin cells
GJ Félix-Martínez, A Gil, J Segura, J Villanueva, LM Gutíerrez
Comput Biol Med 100, 165-175 (2018)
Screening models for undiagnosed diabetes in Mexican adults using clinical and self-reported information
GJ Félix-Martínez, JR Godínez-Fernández
Endocrinol Diabetes Nutr 65 (10), 603-610 (2018)
Modeling the spatiotemporal distribution of Ca2+ during action potential firing in human pancreatic β-cells
GJ Félix-Martínez, JR Godínez-Fernández
Biomed. Phys. Eng. Express 3 025020 (2017)
Effects of Impaired ATP Production and Glucose Sensitivity on Human β-Cell Function: A Simulation Study
GJ Félix-Martínez, J Aspiroz-Leehan, R Ávila-Pozos, JR Godínez-Fernández
Rev Mex Ing Biomed, 35 (2) 2014